All rights reserved. , Petri M. Iaccarino L The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Accessibility Touma Z Once two investigators (E.C., M.P.) , Taghavi-Zadeh S , Trendelenburg M 2. , Esdaile JM. Gordon C The index has proved quick and easy to use despite a comprehensive database and compares favourably with . Systemic Lupus Erythematosus (SLE) Treatment & Management - Medscape Correlations with other instruments measuring similar constructs should typically demonstrate a coefficient (r) 0.50 [106]. X 20 Physician Global Assessment 10.1136/lupus-2019-lsm.176 . Fanouriakis A CLOSED ANGLE/ ANGLE CLOSURE GLAUCOMA. SLE is an immune-mediated multisystemic disease characterized by a wide variability of clinical manifestations and a course frequently subject to unpredictable flares [1, 2]. , Jolly M. Mok CC Elevation of erythrocyte sedimentation rate is associated with disease activity and damage accrual, The systemic lupus activity measure-revised, the Mexican systemic lupus erythematosus disease activity index (SLEDAI), and a modified SLEDAI-2K are adequate instruments to measure disease activity in systemic lupus erythematosus, Small changes in outpatients lupus activity are better detected by clinical instruments than by laboratory tests, Development and initial validation of the systemic lupus erythematosus disease activity index 2000 responder index 50, Sensitivity to change of 3 systemic lupus erythematosus disease activity indices: international validation, Systemic Lupus Erythematosus Disease Activity Index 2000 Responder Index 50: sensitivity to response at 6 and 12 months, Validation of the functional assessment of chronic illness therapy-fatigue scale in patients with moderately to severely active systemic lupus erythematosus, participating in a clinical trial, Psychological distress and changes in the activity of systemic lupus erythematosus, The rating scale preference measure as an evaluative measure in systemic lupus erythematosus, Comparison of the validity and sensitivity to change of 5 activity indices in systemic lupus erythematosus, Treatment of systemic lupus erythematosus with dehydroepiandrosterone: 50 patients treated up to 12 months, Soluble urokinase plasminogen activator receptor levels reflect organ damage in systemic lupus erythematosus, Epratuzumab for patients with moderate to severe flaring SLE: health-related quality of life outcomes and corticosteroid use in the randomized controlled ALLEVIATE trials and extension study SL0006, Measuring systemic lupus erythematosus activity during pregnancy: validation of the lupus activity index in pregnancy scale, Autoantibodies against albumin in patients with systemic lupus erythematosus, Association of depression with socioeconomic status, anticardiolipin antibodies, and organ damage in patients with systemic lupus erythematosus: results from the KORNET registry, Placebo-controlled randomized clinical trial of fish oils impact on fatigue, quality of life, and disease activity in systemic lupus erythematosus, Serum free light chains, interferon-alpha, and interleukins in systemic lupus erythematosus, Vitamin D levels in Chinese patients with systemic lupus erythematosus: relationship with disease activity, vascular risk factors and atherosclerosis, Systemic lupus erythematosus disease activity index 2000 responder index-50: a reliable index for measuring improvement in disease activity, Testosterone patches in the management of patients with mild/moderate systemic lupus erythematosus, Turkish LupusPRO: cross-cultural validation study for lupus, Cross-cultural validation of a disease-specific patient-reported outcome measure for lupus in Philippines, Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: a randomised, placebo-controlled, phase 3 trial, Sensitivity and specificity of plasma and urine complement split products as indicators of lupus disease activity, The TNF locus is altered in monocytes from patients with systemic lupus erythematosus, Effect of pregnancy on disease flares in patients with systemic lupus erythematosus, Frequency of lupus flare in pregnancy: the Hopkins Lupus Pregnancy Center experience, Morbidity of systemic lupus erythematosus: role of race and socioeconomic status, Classification and definition of major flares in SLE clinical trials, Efficacy and safety of epratuzumab in patients with moderate/severe active systemic lupus erythematosus: results from EMBLEM, a phase IIb, randomised, double-blind, placebo-controlled, multicentre study, COSMIN guideline for systematic reviews of patient-reported outcome measures, Validity and reliability in social science research, Understanding the minimum clinically important difference: a review of concepts and methods, Statistical significant change versus relevant or important change in (quasi) experimental design: some conceptual and methodological problems in estimating magnitude of intervention-related change in health services research, Minimum important difference between patients with rheumatoid arthritis: the patients perspective, Responsiveness and sensitivity to change of SLE disease activity measures, The Author(s) 2020. , Hennis A. Jesus D , Bentow C 25 (FIVE YEARS 8) Latest Documents Most Cited Documents Contributed Authors Related Sources Related Keywords Latest Documents; Most Cited Documents; Contributed Authors; Related Sources; 2) [10, 23, 24, 26, 28, 29, 35, 54, 68, 76, 84, 99], with the SLAM in 4 studies (r=0.470.65) [35, 76, 84, 99], with LAI in 2 studies (r=0.640.75) [68, 84], with BILAG in 2 studies (r=0.610.62) [35, 84] and with ECLAM in 2 studies (r=0.580.65) [35, 84]. Patient-Reported Outcomes in Systemic Lupus Erythematosus. et al. Supervise the development of junior medical affairs staff . Liang et al. Vil LM CareerBuilder TIP. The Physician Global Assessment International Standardisation COnsensus in Systemic Lupus Erythematosus (PISCOS) study aimed to obtain an evidence-based and expert-based consensus standardisation of the Physician Global Assessment (PGA) scoring of disease activity in systemic lupus erythematosus (SLE). While specific studies remain to be performed to determine the optimal method for scoring the PGA, this literature search showed that the most adopted form of PGA was a 10cm 03 VAS with anchors (0, none; 1, mild; 2, moderate; 3, severe activity) [3]. The Janus kinase (Jak)/signal transducer and activating protein (STAT) pathways mediate the intracellular signaling of cytokines in a wide spectrum of cellular processes. PDF Getting To Know Dr. Derek Shendell, New Safe Schools Project Director Despite the need for new treatments in CLE . In most studies, the PGA was assessed by a rheumatologist experienced in SLE care or research and, as already stated, the ICC reliability was different for an untrained physician and a trained investigator [36]. , Ibanez D , Askanase A Careers. , Koutsoviti S The SRI is a validated SLE disease activity instrument used to detect clinically meaningful improvement of disease in SLE clinical trials. In one open-label study [43], the decrease in PGA score was considered the primary endpoint. et al. , Larson MG , Gomez A Unable to load your collection due to an error, Unable to load your delegates due to an error. , Siega-Riz AM , Bouter LM Systemic Lupus Erythematosus and Lupus Nephritis - Epidemiology , Flower C Finally, the PGA enables the measurement of disease activity globally compared with a glossary-based index. et al. , Farewell V Mokkink LB Content validity pertains to the degree to which the instrument measures all facets of a construct of interest [20]: this property is satisfied if the PGA is considered able to measure all aspects of disease activity in SLE in a comprehensive way. 2022 Sep 20;19(19):11895. doi: 10.3390/ijerph191911895. Physician's global assessment is often useful in SLE - ResearchGate Mayara Torres Silva de Oliveira, MD, MBA on LinkedIn: #medicinanuclear Can Lupus Patients Take the Driver's Seat in Their Disease Monitoring. , Rodrigues M et al. Fatigue is independently associated with disease activity assessed using the Physician Global Assessment but not the SLEDAI in patients with systemic lupus erythematosus. Reliability. The literature search identified 91 studies. SLE231 Hydrology and Water Resources Management: Excursion or Virtual Tour Management of systemic lupus erythematosus (SLE) often depends on disease severity and disease manifestations, [] although hydroxychloroquine has a central role for long-term treatment in all SLE patients. PGA is a valid, responsive and feasible instrument, while its reliability was impacted by the scale adopted, suggesting the major need for a standardization of its scoring. Montreal, Canada Area. , Brunetta P The Physician's Global Assessment (PhGA) is a number without unit. Petri M PGA or SGA described in ePROVIDE - Mapi Research Trust , Floris A Kiani AN In our centre, new tools for the assessment of SLE activity: the Lupus Activity Scoring Tool (LAST) and Clinical Lupus Activity Scoring Tool (C-LAST) were developed and validated. Annapureddy N et al. In the last 30years, more than a dozen scores have been derived to assess disease activity in SLE, but not all of these have proven to be valid and reliable tools. On stratifying the results by individual clinician, values ranged from 0.61 to 0.90, except for those reported by . , Stavrakis S Content validity was reported in 89 studies. , Shinada S Definition: At least a 20%, 40%, 50%, or 70% improvement and an absolute improvement of at least 1 unit on a scale of 1-10 in at least three of the following criteria: patient global assessment; pain; function (BASFI); and. A validation study of the SRI for juvenile SLE [60] showed that exclusion of the BILAG or PGA from the SRI did not change the accuracy of the SRI in detecting improvement. Objective Existing methods for grading lupus flares or improvement require definition-based thresholds as increments of change. Bookshelf Search for other works by this author on: Rheumatology Unit, AOU University Clinic and University of Cagliari, Department of Medical Sciences and Public Health, Cagliari, Italy, Centre Hospitalier Universitaire de Dijon, Hpital Franois-Mitterrand, service de mdecine interne et maladies systmiques (mdecine interne, 2) et Centre dInvestigation Clinique, Service de rhumatologie, Hpitaux Universitaires de Strasbourg, Universit de Strasbourg, Centre National de Rfrence des Maladies Systmiques et Autoimmunes Rares Est Sud-Ouest (RESO). Patient global assessment (PGA) is one of the most widely used PROs in RA practice and research and is included in several composite scores such as the 28-joint Disease Activity Score (DAS28). et al. , Sayedbonakdar Z Gandhi N Piga M No data were found regarding the feasibility of the PGA. , Morabito LM The aim of this systematic literature review is to describe and analyse the psychometric properties of the PGA. This property is reported across all articles selected through this systematic review [24, 913, 21103]. , Skogh T et al. All rights reserved. For your privacy and protection, when applying to a job online, never give your social security number to a prospective employer, provide credit card or bank account information, or perform any sort of monetary transaction. The last MEDLINE search was performed on 1 July 2019. , Mohan C. Jolly M , Petri M. Thanou A , Wallace DJ The Patient's Global Assessment Scale (PGA) is the PRO counterpart to the Physician's Global Assessment Scale or Investigator's Global Assessment Scale (PGA-IGA). Medical-Surgical Nursing Clinical Lab (NUR1211L) U.S. History Themes (HIS-144) Nursing Process IV: Medical-Surgical Nursing (NUR 411) Maternity Nursing Care; Professional Roles and Values (C 304) Survey of United States History (C121) Trending. Uribe AG, Vil LM, McGwin G Jr, Sanchez ML, Reveille JD, Alarcn GS. 2022 May;9(1):e000700. Medical Cannabis Use by Rheumatology Patients Following Recreational 2022 Sep;8(2):e002395. , Jnsen A However, it was used as a single outcome measure only in two studies [49, 100], while in the majority the PGA was scored together with another instrument (typically the SLEDAI) [2, 9, 11, 12, 21, 24, 30, 32, 34, 3740, 44, 45, 48, 49, 55, 58, 59, 61, 63, 64, 66, 67, 74, 75, 80, 82, 86, 8995, 103]. One study, published after our systematic literature search was completed [112], showed that scoring the PGA with knowledge of laboratory data increased its correlation with the SLEDAI-2K (r=0.79) compared with without knowledge of laboratory results (r=0.67). Parodis I , Genovese M A good responsiveness for PGA was shown in eight studies. disease activity in SLE, with the Physician Global Assessment (PGA) being the only one included in the updated EULAR recommendations for the management of SLE.11. Measurement properties of the PGA were analysed according to the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) terminology [19]. watch for seizures after the procedure. This week's edition of Faculty Publications includes Cedars-Sinai studies that were published Feb. 23-March 2. et al. Ward et al. It can affect the joints, skin, brain, lungs, kidneys, and blood vessels. This scoring modality was used for the SRI [3]. It estimates how similar a given patients scores were at the two visits. http://oml.eular.org/glossary (31 January. van Vollenhoven R [80] considered worsening as any increase in the PGA from baseline; in the epratuzumab trial [87], a significant improvement was a 20% decrease in the PGA score evaluated after 12months of treatment. (PGA) scoring of disease activity in systemic lupus erythematosus (SLE). Criterion validity data reporting correlation coefficients between PGA and quality of life measures, laboratory markers and miscellaneous. Navarra SV Even though the PGA showed optimal reliability, a very low interRR for flare using the PGA (ICC=0.18) was found in a single study [65] compared with that of the BILAG (ICC=0.54) or SFI (ICC=0.21). , Criscione-Schreiber LG Navarra SV Systemic lupus erythematosus (SLE) is a multisystem autoimmune rheumatic disease (ARD) characterized by flares and remissions. , Leung HW et al. For full access to this pdf, sign in to an existing account, or purchase an annual subscription. Associations between physicians' global assessment of disease activity , Jolly M. Mazur-Nicorici L Diet and Systemic Lupus Erythematosus (SLE): From Supplementation to Intervention. , Terwee CB et al. Jesus D How does one assess and monitor patients with systemic lupus Randomized MMF Withdrawal in Systemic Lupus Erythematosus (SLE) - Full Objective: To examine the feasibility of using Physician Global Assessment (PGA) scores to collect and track patient acne and . Patient global assessment (PGA) is one of the most widely used PROs in RA practice and research and is included in several composite scores such as the 28-joint Disease Activity Score (DAS28). Criterion validity is defined as the degree to which the scores of an instrument adequately reflect the truth in the form of a gold standard [107]. Construct validity was demonstrated by a good correlation (r0.50) between the PGA with the SLEDAI (12 studies), SLAM (4 studies), LAI, BILAG and ECLAM (2 studies each). Compared with nonresponders, BICLA responders had greater improvements in global and organ-specific disease activity (Physician's Global Assessment, SLE Disease Activity Index 2000, Cutaneous Lupus Erythematosus Disease Area and Severity Index Activity, and joint counts; all nominal P < 0.001). et al. et al. Flow chart illustrating the literature search and study selection. Provide oversight to Shared Services Derivatives team supporting RWA operations and production. Physician training is very important. A Comprehensive Digest of Research Publications From Cedars-Sinai Investigators. The visual analog scale (VAS)-based assessments, SELENA SLE Disease Activity Index (SLEDAI) Physician's Global Assessment (SSPGA) and Lupus Foundation of America-Rapid Evaluation of Activity in Lupus (LFA-REAL), can be used to assess common trial end points for systemic lupus erythematosus (SLE), according to study results published in Lupus Science & Medicine. et al. The aim of this systematic literature review is to describe and analyse the . , Subach RB The Systemic Lupus Activity Measure-revised, the Mexican Systemic Lupus Erythematosus Disease Activity Index (SLEDAI), and a modified SLEDAI-2K are adequate instruments to measure disease activity in systemic lupus erythematosus. , Ogale S In Fatemi et al. physician global assessment Recently Published Documents. Observed and articulated management issues and responses. , Sengupta M , Lau CS [2, 21, 24] recommended PGA assessment prior to reviewing serological data, based only on the clinical visit. Discrimination refers to whether the score (PGA-VAS) differentiates between situations of interest [18]: discrimination of the PGA measures the ability of the PGA-VAS to report a consistent score where no change in disease activity has occurred (reliability) and to detect a change when a change in disease activity has occurred (sensitivity to change or responsiveness). , Henriques C SLE2ACR1997SLICC2012. Face validity is satisfied when the instrument is considered able to capture what it should capture (i.e. Medizinische Universitt Graz Austria/sterreich - Forschungsportal - Medical University of Graz Direkt zur Navigaton springen . , Holland M antineutrophil cytoplasmic antibody-associated vasculitis (AAV), and systemic lupus erythematosus (SLE). AU - Louthrenoo, Worawit. Strength. Background: Physician Global Assessment (PGA) is a visual analogue score (VAS) that reflects the clinician's judgment of overall Systemic Lupus Erythematosus (SLE) disease activity. Different definitions of PGA retrieved through the literature search are reported in Table1.
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